Tears Naturale

1. Name Of The Medicinal Product

Tears Naturale

2. Qualitative And Quantitative Composition

Dextran 70 0.1% w/v

Hypromellose 0.3% w/v

3. Pharmaceutical Form

Eye drops, solution.

4. Clinical Particulars

4.1 Therapeutic Indications

As a lubricant and artificial tear in dry eye and other ocular irritation syndromes associated with deficient tear or mucous secretion.

4.2 Posology And Method Of Administration

Adults, children and the elderly:

One or two drops as required or directed instilled into the conjunctival sac.

4.3 Contraindications

Hypersensitivity to dextran 70, hypromellose or to any of the excipients.

4.4 Special Warnings And Precautions For Use

• For ocular use only. Not for injection or ingestion.

• Tears Naturale contains benzalkonium chloride which may cause eye irritation and is known to discolour soft contact lenses. Contact with soft contact lenses is to be avoided. Patients should be advised to remove their contact lenses prior to the application of Tears Natural and wait at least 15 minutes before reinsertion.

• If patients experience headache, eye pain, vision changes, irritation of the eyes, persistent redness, or if the condition worsens or persists for more than 3 days, they are to discontinue use and consult their doctor.

4.5 Interaction With Other Medicinal Products And Other Forms Of Interaction

If more than one topical ophthalmic medicinal product is being used, the medicines must be administered at least 5 minutes apart. Eye ointments should be administered last.

4.6 Pregnancy And Lactation

Pregnancy

There are no or limited amount of data from the use of Tears Naturale in pregnant women. However, the components dextran 70 and hypromellose exert a surface protective effect and are not pharmacologically active. These components are not expected to be absorbed systemically, to demonstrate any systemic toxicity or to have any effect on reproduction or embryofetal development. Tears Naturale can be used during pregnancy.

Lactation

It is unknown whether dextran 70, hypromellose or any of the components are excreted in human milk. Nonetheless, discontinuation of product use during breast-feeding is not considered necessary. Tears Naturale can be used during breast-feeding.

4.7 Effects On Ability To Drive And Use Machines

Tears Naturale has no or negligible influence on the ability to drive or use machines. As with any eye drops, temporary blurred vision or other visual disturbances may affect the ability to drive or use machines. If blurred vision occurs at instillation, the patient must wait until the vision clears before driving or using machines.

4.8 Undesirable Effects

a. Summary of the safety profile

The most frequently occurring adverse reaction during clinical trials was vision blurred.

b. Tabulated list of adverse reactions

The following adverse reactions are classified according to the following convention: very common (

System Organ Classification	MedDRA Preferred Term (v.12.0)
Immune system disorders	Not known: hypersensitivity
Nervous system disorders	Uncommon: headache
Eye disorders	Very common: vision blurred Common: dry eye (residual), eyelid disorder, abnormal sensation in eye, foreign body sensation in eyes, ocular discomfort. Uncommon: photophobia, hypoaesthesia eye, eye pruritus, eye irritation, ocular hyperaemia. Not known: erythema of eyelid, eye swelling, eye pain, eye discharge, eyelid margin crusting, lacrimation increased.
General disorders and administration site conditions	Uncommon: discomfort (skin)

4.9 Overdose

• No case of overdose has been reported.

• An overdose of Tears Naturale can easily be washed out of the eye with lukewarm tap water.

5. Pharmacological Properties

5.1 Pharmacodynamic Properties

Pharmacotherapeutic Group: Artificial Tears

ATC Code: S01X A

The combination of Dextran 70 and hypromellose in an aqueous presentation provides a soothing lubricant preparation for the relief of dry eye syndrome associated with deficient tear secretion or deficient mucous.

5.2 Pharmacokinetic Properties

Not applicable.

5.3 Preclinical Safety Data

There are no preclinical data of relevance to the prescriber which are additional to that already included in other sections of the SPC.

6. Pharmaceutical Particulars

6.1 List Of Excipients

Benzalkonium chloride

Disodium edetate

Sodium chloride

Potassium chloride

Sodium hydroxide and/or Hydrochloric acid

Purified water

6.2 Incompatibilities

None known.

6.3 Shelf Life

3 years (unopened).

1 month after first opening.

6.4 Special Precautions For Storage

Do not store above 25°C.

Do not refrigerate.

Keep container tightly closed.

Discard one month after opening.

6.5 Nature And Contents Of Container

15 ml Drop-Tainer – Low density polyethylene dropper bottle with white polypropylene cap and LDPE tip.

6.6 Special Precautions For Disposal And Other Handling

None.

Administrative Data

7. Marketing Authorisation Holder

Alcon Laboratories (UK) Ltd.,

Pentagon Park,

Boundary Way,

Hemel Hempstead,

Herts., HP2 7UD

United Kingdom

8. Marketing Authorisation Number(S)

PL 0649/0031

9. Date Of First Authorisation/Renewal Of The Authorisation

6th July 1979 / 12th September 1995

10. Date Of Revision Of The Text

07/09/2010

Tobramycin

Pronunciation: TOE-bra-MYE-sin
Generic Name: Tobramycin
Brand Name: Nebcin

Tobramycin has caused kidney problems, nerve damage, or permanent hearing loss, even at usual doses. Hearing loss can occur even after the medicine is stopped. If you already have kidney problems or hearing difficulty, tell your doctor. Notify your doctor right away if any of the following occur: ringing in ears, hearing loss, unusual change in amount of urine, dizziness, numbness, skin tingling, muscle twitching, or seizures. Tobramycin may be stopped if you develop kidney or hearing problems. Your doctor will monitor your progress to minimize the possibility of these effects occurring and to run certain tests (eg, hearing and/or kidney tests). Do not use Tobramycin with other medicines that can cause nerve, kidney, or hearing problems. Other factors that increase the risk of these side effects occurring include premature and newborn infants, advanced age, or dehydration. Avoid other medicines that may harm the kidneys or decrease hearing (eg, other aminoglycosides [eg, gentamicin], cephaloridine, viomycin, polymyxin B, colistin, cisplatin, vancomycin) while you are using Tobramycin. Do not use Tobramycin with certain diuretics (eg, furosemide, ethacrynic acid).

Tobramycin may cause fetal harm if used during pregnancy.

Tobramycin is used for:

Treating serious infections caused by certain bacteria.

Tobramycin is an aminoglycoside antibiotic. It works by killing sensitive bacteria.

Do NOT use Tobramycin if:

• you are allergic to any ingredient in Tobramycin or another aminoglycoside antibiotic (eg, gentamicin)


• you are taking certain diuretics (eg, furosemide, ethacrynic acid), cyclosporine, methoxyflurane, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tobramycin:

Some medical conditions may interact with Tobramycin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have myasthenia gravis (a condition in which the muscles become progressively paralyzed) or Parkinson disease


• if you have hearing problems, nerve problems, kidney problems, or severe or extensive burns, or you are dehydrated

Some MEDICINES MAY INTERACT with Tobramycin. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Cephaloridine, cephalosporins (eg, ceftizoxime), cisplatin, colistin, cyclosporine, fludarabine, loop diuretics (eg, furosemide, ethacrynic acid), methoxyflurane, nitrosoureas (eg, carmustine), NSAIDs (eg, ibuprofen), polymyxin B, vancomycin, or viomycin because they may increase the risk of Tobramycin's side effects, including increased risk of kidney or hearing loss


• Beta-lactam antibiotics (eg, penicillin, imipenem, ceftizoxime) because they may decrease Tobramycin's effectiveness


• Nondepolarizing muscle relaxants (eg, atracurium) or succinylcholine because the risk of their side effects may be increased by Tobramycin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tobramycin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tobramycin:

Use Tobramycin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Tobramycin is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Tobramycin at home, a health care provider will teach you how to use it. Be sure you understand how to use Tobramycin. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.


• Do not use Tobramycin if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.


• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.


• If you miss a dose of Tobramycin, use it as soon as possible. Check with your doctor or pharmacist for instructions on scheduling other doses.

Ask your health care provider any questions you may have about how to use Tobramycin.

Important safety information:

• Tobramycin only works against bacteria; it does not treat viral infections (eg, the common cold).


• Drinking extra fluids while you are using Tobramycin is recommended. Check with your doctor for instructions.


• Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.


• Be sure to use Tobramycin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• Long-term or repeated use of Tobramycin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.


• Some of these products contain sulfites. Sulfites may cause an allergic reaction in some patients (eg, asthma patients). If you have ever had an allergic reaction to sulfites, ask your pharmacist if your product has sulfites in it.


• Tell your doctor or dentist that you take Tobramycin before you receive any medical or dental care, emergency care, or surgery.


• Lab tests, including kidney function, hearing tests, blood electrolyte levels, and tobramycin levels, may be performed while you use Tobramycin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Tobramycin with caution in the ELDERLY; they may be more sensitive to its effects, especially kidney or hearing problems.


• Tobramycin should be used with extreme caution in CHILDREN younger than 10 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Tobramycin has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Tobramycin while you are pregnant. It is not known if Tobramycin is found in breast milk. Do not breast-feed while taking Tobramycin.

Possible side effects of Tobramycin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; nausea; pain, swelling, or redness at the injection site; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); clumsiness; confusion; decreased hearing or other hearing changes; decreased urination; dizziness or lightheadedness; feeling of a whirling motion; fever, chills, or persistent sore throat; hearing loss; loss of coordination; muscle weakness; numbness or tingling; red, swollen, blistered, or peeling skin; ringing or roaring in the ears; seizures; severe or persistent diarrhea; stomach pain or cramps; unusual bruising or bleeding; vaginal irritation or discharge.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms include decreased urination; dizziness; hearing loss; trouble breathing.

Proper storage of Tobramycin:

Tobramycin is usually handled and stored by a health care provider. If you are using Tobramycin at home, store Tobramycin as directed by your pharmacist or health care provider. Keep Tobramycin, as well as syringes and needles, out of the reach of children and away from pets.

General information:

• If you have any questions about Tobramycin, please talk with your doctor, pharmacist, or other health care provider.


• Tobramycin is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Tobramycin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Tobramycin resources

• Tobramycin Use in Pregnancy & Breastfeeding
• Tobramycin Drug Interactions
• Tobramycin Support Group
• 0 Reviews for Tobramycin - Add your own review/rating

• Tobramycin Professional Patient Advice (Wolters Kluwer)


• Tobramycin eent Monograph (AHFS DI)


• Tobramycin Prescribing Information (FDA)


• tobramycin Inhalation Advanced Consumer (Micromedex) - Includes Dosage Information


• tobramycin inhalation Concise Consumer Information (Cerner Multum)


• Nebcin injection Concise Consumer Information (Cerner Multum)


• Nebcin Advanced Consumer (Micromedex) - Includes Dosage Information


• Tobi Monograph (AHFS DI)


• Tobi Prescribing Information (FDA)

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• Intraabdominal Infection
• Kidney Infections
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• Shunt Infection
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Tranxene T-Tab

Generic Name: clorazepate (klor AZ e pate)

Brand Names: Tranxene SD, Tranxene T-Tab

What is Tranxene T-Tab (clorazepate)?

Clorazepate is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Clorazepate affects chemicals in the brain that may become unbalanced and cause anxiety or seizures.

Clorazepate is used to treat anxiety disorders, partial seizures, or alcohol withdrawal symptoms.

Clorazepate may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Tranxene T-Tab (clorazepate)?

Do not use this medication if you are allergic to clorazepate or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax). This medication can cause birth defects in an unborn baby. Do not use clorazepate if you are pregnant.

Before taking clorazepate, tell your doctor if you have any breathing problems, glaucoma, kidney or liver disease, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol.

Video: Treatment for Depression

Treatments for depression are getting better everyday and there are things you can start doing right away.

Do not drink alcohol while taking clorazepate. This medication can increase the effects of alcohol.

Avoid using other medicines that make you sleepy. They can add to sleepiness caused by clorazepate.

Clorazepate may be habit-forming and should be used only by the person it was prescribed for. Clorazepate should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

What should I discuss with my healthcare provider before taking Tranxene T-Tab (clorazepate)?

Do not use this medication if you have narrow-angle glaucoma, or if you are allergic to clorazepate or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Before taking clorazepate, tell your doctor if you are allergic to any drugs, or if you have:

• 
  

  glaucoma;

  
  


• 
  

  asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;

  
  


• 
  

  kidney or liver disease;

  
  


• 
  

  epilepsy or other seizure disorder;

  
  


• 
  

  a history of depression or suicidal thoughts or behavior; or

  
  


• 
  

  a history of drug or alcohol addiction.

  
  

If you have any of these conditions, you may need a dose adjustment or special tests during treatment.

Clorazepate can cause birth defects in an unborn baby. Do not use clorazepate without your doctor's consent if you are pregnant. Tell your doctor if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Clorazepate can pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

The sedative effects of clorazepate may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking clorazepate.

Do not give this medication to a child younger than 9 years old.

How should I take Tranxene T-Tab (clorazepate)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Clorazepate should be used for only a short time. Do not take this medication for longer than 4 months without your doctor's advice. Clorazepate may be habit-forming and should be used only by the person it was prescribed for. Clorazepate should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Contact your doctor if this medicine seems to stop working as well in treating your anxiety symptoms. Do not stop using clorazepate suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

Your symptoms may return when you stop using clorazepate after using it over a long period of time. You may also have withdrawal symptoms when you stop using clorazepate. Withdrawal symptoms may include tremor, sweating, trouble sleeping, muscle cramps, stomach pain, vomiting, diarrhea, irritability, memory problems, confusion, unusual thoughts or behavior, and seizure (convulsions).

To be sure this medication is not causing harmful effects, your blood and liver function may need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

Store clorazepate at room temperature away from moisture, heat, and light.

Keep track of how many pills have been used from each new bottle of this medicine. Benzodiazepines are drugs of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

See also: Tranxene T-Tab dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of clorazepate can be fatal.

Overdose symptoms may include extreme drowsiness, feeling light-headed, fainting, or coma.

What should I avoid while taking Tranxene T-Tab (clorazepate)?

Do not drink alcohol while taking clorazepate. This medication can increase the effects of alcohol. Clorazepate can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by clorazepate.

Tranxene T-Tab (clorazepate) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  confusion, unusual thoughts or behavior;

  
  


• 
  

  depressed mood, thoughts of suicide or hurting yourself;

  
  


• 
  

  muscle twitching, tremor; or

  
  


• 
  

  problems with urination.

  
  

Less serious side effects may include:

• 
  

  drowsiness, tiredness;

  
  


• 
  

  amnesia or forgetfulness;

  
  


• 
  

  dizziness;

  
  


• 
  

  blurred vision;

  
  


• 
  

  feeling nervous or irritable;

  
  


• 
  

  sleep problems (insomnia);

  
  


• 
  

  muscle weakness, lack of balance or coordination;

  
  


• 
  

  skin rash;

  
  


• 
  

  nausea, vomiting, stomach pain, constipation; or

  
  


• 
  

  dry mouth; or

  
  


• 
  

  headache.

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Tranxene T-Tab (clorazepate)?

Before taking clorazepate, tell your doctor if you are taking any other anti-anxiety medications, or if you are using any of the following drugs:

• 
  

  a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);

  
  


• 
  

  an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate);

  
  


• 
  

  medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril);

  
  


• 
  

  narcotic medications such as butorphanol (Stadol), codeine, hydrocodone (Lortab, Vicodin), levorphanol (Levo-Dromoran), meperidine (Demerol), methadone (Dolophine, Methadose), morphine (Kadian, MS Contin, Oramorph), naloxone (Narcan), oxycodone (OxyContin), propoxyphene (Darvon, Darvocet); or

  
  


• 
  

  antidepressants such as amitriptyline (Elavil, Etrafon), amoxapine (Asendin), citalopram (Celexa), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), protriptyline (Vivactil), sertraline (Zoloft), or trimipramine (Surmontil).

  
  

This list is not complete and there may be other drugs that can interact with clorazepate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Tranxene T-Tab resources

• Tranxene T-Tab Side Effects (in more detail)
• Tranxene T-Tab Dosage
• Tranxene T-Tab Use in Pregnancy & Breastfeeding
• Drug Images
• Tranxene T-Tab Drug Interactions
• Tranxene T-Tab Support Group
• 0 Reviews for Tranxene T-Tab - Add your own review/rating

• Tranxene T-Tab MedFacts Consumer Leaflet (Wolters Kluwer)


• Tranxene T-Tab Advanced Consumer (Micromedex) - Includes Dosage Information


• Tranxene T-Tab Prescribing Information (FDA)


• Clorazepate Prescribing Information (FDA)


• Clorazepate Dipotassium Monograph (AHFS DI)

Compare Tranxene T-Tab with other medications

• Alcohol Withdrawal
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Where can I get more information?

• Your pharmacist can provide more information about clorazepate.

See also: Tranxene T-Tab side effects (in more detail)

Teramine

Generic Name: phentermine (FEN ter meen)

Brand Names: Adipex-P, Oby-Cap, T-Diet, Zantryl

What is Teramine (phentermine)?

Phentermine is a stimulant that is similar to an amphetamine. Phentermine is an appetite suppressant that affects the central nervous system.

Phentermine is used togther with diet and exercise to treat obesity (overweight) in people with risk factors such as high blood pressure, high cholesterol, or diabetes.

Phentermine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Teramine (phentermine)?

Taking phentermine together with other diet medications such as fenfluramine (Phen-Fen) or dexfenfluramine (Redux) can cause a rare fatal lung disorder called pulmonary hypertension. Do not take phentermine with any other diet medications without your doctor's advice.

Phentermine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of phentermine.

Phentermine is only part of a complete program of treatment that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Phentermine may be habit-forming and should be used only by the person it was prescribed for. Never share phentermine with another person, especially someone with a history of drug abuse or addiction. Keep track of the amount of medicine used from each new bottle. Phentermine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription. Do not stop using phentermine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using phentermine.

What should I discuss with my healthcare provider before taking Teramine (phentermine)?

Do not use phentermine if you have taken an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) in the last 14 days. Serious, life threatening side effects can occur if you use phentermine before the MAO inhibitor has cleared from your body.

Taking phentermine together with other diet medications such as fenfluramine (Phen-Fen) or dexfenfluramine (Redux) can cause a rare fatal lung disorder called pulmonary hypertension. Do not take phentermine with any other diet medications without your doctor's advice.

You should not take phentermine if you are allergic to it, or if you have:

• 
  

  coronary artery disease (hardening of the arteries);

  
  


• 
  

  heart disease;

  
  


• 
  

  severe or uncontrolled high blood pressure;

  
  


• 
  

  overactive thyroid;

  
  


• 
  

  glaucoma;

  
  


• 
  

  if you have a history of drug or alcohol abuse; o

  
  


• 
  

  if you are allergic to other diet pills, amphetamines, stimulants, or cold medications.

  
  

If you have any of these other conditions, you may need a phentermine dose adjustment or special tests:

• 
  

  high blood pressure;

  
  


• 
  

  diabetes; or

  
  


• 
  

  a thyroid disorder.

  
  

FDA pregnancy category C. It is not known whether phentermine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Phentermine can pass into breast milk and may harm a nursing baby. You should not breast-feed while taking phentermine. Do not give this medication to a child younger than 16 years old. Phentermine may be habit-forming and should be used only by the person it was prescribed for. Never share phentermine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

How should I take Teramine (phentermine)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

It is best to take phentermine on an empty stomach before breakfast or within 2 hours after breakfast.

To prevent sleep problems, take this medication early in the day, no later than 6:00 pm.

Talk with your doctor if you have increased hunger or if you otherwise think the medication is not working properly. Taking more of this medication will not make it more effective and can cause serious, life-threatening side effects.

Phentermine should be taken only for a short time, such as a few weeks.

Do not stop taking phentermine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using phentermine. Store at room temperature away from moisture and heat. Keep track of the amount of medicine used from each new bottle. Phentermine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of phentermine can be fatal.

Overdose symptoms may include confusion, hallucinations, panic, feeling hostile or aggressive, nausea, vomiting, diarrhea, stomach cramps, irregular heartbeat, rapid breathing, overactive reflexes, confusion, hallucinations, seizure (convulsions), feeling light-headed, or fainting.

What should I avoid while taking Teramine (phentermine)?

Drinking alcohol can increase certain side effects of phentermine. Phentermine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Teramine (phentermine) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

• 
  

  feeling short of breath, even with mild exertion;

  
  


• 
  

  chest pain, feeling like you might pass out;

  
  


• 
  

  swelling in your ankles or feet;

  
  


• 
  

  pounding heartbeats or fluttering in your chest;

  
  


• 
  

  confusion or irritability, unusual thoughts or behavior;

  
  


• 
  

  feelings of extreme happiness or sadness; or

  
  


• 
  

  dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

  
  

Less serious side effects may include:

• 
  

  feeling restless or hyperactive;

  
  


• 
  

  headache, dizziness, tremors;

  
  


• 
  

  sleep problems (insomnia);

  
  


• 
  

  dry mouth or an unpleasant taste in your mouth;

  
  


• 
  

  diarrhea or constipation, upset stomach; or

  
  


• 
  

  increased or decreased interest in sex, impotence.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Teramine (phentermine)?

Tell your doctor about all other medicines you use, especially:

• 
  

  blood pressure medications;

  
  


• 
  

  insulin or oral diabetes medication;

  
  


• 
  

  guanethidine (Ismelin); or

  
  


• 
  

  an antidepressant such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Symbyax), paroxetine (Paxil), sertraline (Zoloft), and others.

  
  

This list is not complete and other drugs may interact with phentermine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Teramine resources

• Teramine Side Effects (in more detail)
• Teramine Use in Pregnancy & Breastfeeding
• Teramine Drug Interactions
• Teramine Support Group
• 0 Reviews for Teramine - Add your own review/rating

• Phentermine Prescribing Information (FDA)


• Phentermine Monograph (AHFS DI)


• Adipex-P MedFacts Consumer Leaflet (Wolters Kluwer)


• Adipex-P Prescribing Information (FDA)


• Fastin Advanced Consumer (Micromedex) - Includes Dosage Information


• Ionamin MedFacts Consumer Leaflet (Wolters Kluwer)


• Ionamin Prescribing Information (FDA)

Compare Teramine with other medications

• Obesity
• Weight Loss

Where can I get more information?

• Your pharmacist can provide more information about phentermine.

See also: Teramine side effects (in more detail)

triazolam

trye-AZ-oh-lam

Commonly used brand name(s)

In the U.S.

• Halcion

Available Dosage Forms:

• Tablet

Therapeutic Class: Hypnotic

Pharmacologic Class: Benzodiazepine, Short or Intermediate Acting

Uses For triazolam

Triazolam is used to treat insomnia (trouble with sleeping). triazolam is only for short-term use, usually 7 to 10 days. Triazolam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

triazolam is available only with your doctor's prescription.

Before Using triazolam

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For triazolam, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to triazolam or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of triazolam in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of triazolam in the elderly. However, severe drowsiness, dizziness, confusion, clumsiness, or unsteadiness are more likely to occur in the elderly, which may require an adjustment in the dose for patients receiving triazolam.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	X	Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking triazolam, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using triazolam with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Amprenavir


• Atazanavir


• Boceprevir


• Darunavir


• Delavirdine


• Efavirenz


• Fosamprenavir


• Indinavir


• Itraconazole


• Ketoconazole


• Lopinavir


• Nefazodone


• Nelfinavir


• Ritonavir


• Saquinavir


• Telaprevir


• Tipranavir

Using triazolam with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfentanil


• Amobarbital


• Anileridine


• Aprobarbital


• Butabarbital


• Butalbital


• Carisoprodol


• Chloral Hydrate


• Chlorzoxazone


• Codeine


• Dantrolene


• Ethchlorvynol


• Fentanyl


• Fluconazole


• Fospropofol


• Hydrocodone


• Hydromorphone


• Levorphanol


• Meperidine


• Mephenesin


• Mephobarbital


• Meprobamate


• Metaxalone


• Methocarbamol


• Methohexital


• Mibefradil


• Morphine


• Morphine Sulfate Liposome


• Oxycodone


• Oxymorphone


• Pentobarbital


• Phenobarbital


• Primidone


• Propoxyphene


• Remifentanil


• Secobarbital


• Sodium Oxybate


• Sufentanil


• Tapentadol


• Thiopental


• Voriconazole


• Zolpidem

Using triazolam with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aprepitant


• Clarithromycin


• Dehydroepiandrosterone


• Diltiazem


• Erythromycin


• Fluvoxamine


• Fosaprepitant


• Modafinil


• Omeprazole


• Ranitidine


• Rifampin


• Rifapentine


• Roxithromycin


• Rufinamide


• St John's Wort


• Theophylline


• Troleandomycin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using triazolam with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use triazolam, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of triazolam. Make sure you tell your doctor if you have any other medical problems, especially:

• Alcohol abuse, or history of, or


• Drug abuse or dependence, or history of—Dependence on triazolam may develop.

• Breathing problems or lung disease, severe or


• Depression, or history of, or


• Sleep apnea (temporary stopping of breathing during sleep)—Use with caution. May make these conditions worse.

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of triazolam

Take triazolam only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

Take triazolam just before going to bed, when you are ready to go to sleep.

triazolam should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Dosing

The dose of triazolam will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of triazolam. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage form (tablets):
  
  • For insomnia:
    
    • Adults—0.125 to 0.25 milligram (mg) at bedtime.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Precautions While Using triazolam

It is very important that your doctor check your progress at regular visits to make sure triazolam is working properly. Blood tests may be needed to check for any unwanted effects.

Using triazolam while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

Triazolam may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Stop taking triazolam and call your doctor right away if you have itching, hives, hoarseness, nausea or vomiting, trouble breathing, trouble swallowing, or any swelling of your hands, face, mouth or throat while you are using triazolam.

Do not take itraconazole (Sporanox®), ketoconazole (Nizoral®), or nefazodone (Serzone®) while you are using triazolam. Taking these medicines together with triazolam may increase the chance of serious side effects.

If you develop any unusual or strange thoughts and behavior while taking triazolam, be sure to discuss it with your doctor. Some changes that have occurred in people taking triazolam are like those seen in people who drink too much alcohol. Other changes might be confusion, worsening of depression, hallucinations (seeing, hearing, or feeling things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability.

triazolam may cause sleep-related behaviors such as driving a car (sleep-driving), walking (sleep-walking), having sex, making phone calls, or preparing and eating food while you are asleep or not fully awake. If these reactions occur, tell your doctor right away.

triazolam will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system, which may cause drowsiness or make you less alert. Some examples of CNS depressants are antihistamines or medicine for hay fever, allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates (used for seizures); muscle relaxants; or anesthetics (numbing medicines), including some dental anesthetics. This effect may last for a few days after you stop taking triazolam. Check with your doctor before taking any of the above while you are using triazolam.

triazolam may cause some people, especially older persons, to become drowsy, dizzy, or less alert than they are normally. Even though triazolam is taken at bedtime, it may cause some people to feel drowsy or less alert the next morning. Make sure you know how you react to triazolam before you drive, use machines, or do anything else that could be dangerous if you are dizzy, not alert, or not able to think or see well.

Do not take triazolam when your schedule does not permit you to get a full night's sleep (7 to 8 hours). If you must wake up before this, you may continue to feel drowsy and have memory problems because the effects of the medicine have not had time to wear off.

Do not stop taking triazolam without checking with your doctor first. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a worsening of your condition and reduce the possibility of withdrawal symptoms, such as convulsions (seizures), stomach or muscle cramps, sweating, tremors, vomiting, or unusual behavior.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

If your condition does not improve within 7 to 10 days, or if it becomes worse, check with your doctor.

triazolam Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

• Shakiness and unsteady walk


• unsteadiness, trembling, or other problems with muscle control or coordination

Rare

• Being forgetful


• burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• continuing ringing or buzzing or other unexplained noise in the ears


• discouragement


• false or unusual sense of well-being


• fast, pounding, or irregular heartbeat or pulse


• feeling sad or empty


• hearing loss


• irritability


• lack of appetite


• loss of interest or pleasure


• nightmares


• sleeplessness


• tiredness


• trouble concentrating


• trouble sleeping


• unable to sleep

Incidence not known

• Abdominal or stomach pain


• actions that are out of control


• aggressiveness


• anxiety


• changes in patterns and rhythms of speech


• chest pain


• chills


• clay-colored stools


• confusion about identity, place, and time


• dark urine


• decrease in frequency of urination


• decrease in urine volume


• difficulty in passing urine (dribbling)


• dizziness


• drowsiness


• dry mouth


• environment seems unreal


• fainting


• falling


• false beliefs that cannot be changed by facts


• feeling of unreality


• fever


• headache


• hyperventilation


• inability to move eyes


• increased blinking or spasms of the eyelid


• increased muscle spasm


• irregular heartbeats


• loss of appetite


• loss of bladder control


• loss of memory


• nausea


• nervousness


• nightmares


• painful urination


• problems with memory


• rash


• relaxed and calm


• restlessness


• seeing, hearing, or feeling things that are not there


• sense of detachment from self or body


• shortness of breath


• sleep walking


• sleepiness


• slurred speech


• sticking out of tongue


• talking, feeling, and acting with excitement


• trouble in breathing, speaking, or swallowing


• uncontrolled twisting movements of the neck, trunk, arms, or legs


• unpleasant breath odor


• unusual excitement, nervousness, restlessness, or irritability


• unusual facial expressions


• unusual tiredness or weakness


• vomiting of blood


• yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Lightheadedness

Rare

• Any change in vision


• blistering, crusting, irritation, itching, or reddening of skin


• change in taste or bad, unusual, or unpleasant (after) taste


• cracked, dry, or scaly skin


• cramps


• diarrhea


• difficulty having a bowel movement (stool)


• dry mouth


• swelling


• weakness

Incidence not known

• Decreased interest in sexual intercourse


• inability to have or keep an erection


• increase in sexual ability, desire, drive, or performance


• increase interest in sexual intercourse


• itching skin


• loss in sexual ability, desire, drive, or performance


• menstrual changes


• redness, swelling, or soreness of the tongue


• swelling or inflammation of the mouth


• weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: triazolam side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More triazolam resources

• Triazolam Side Effects (in more detail)
• Triazolam Dosage
• Triazolam Use in Pregnancy & Breastfeeding
• Drug Images
• Triazolam Drug Interactions
• Triazolam Support Group
• 7 Reviews for Triazolam - Add your own review/rating

• triazolam Concise Consumer Information (Cerner Multum)


• Triazolam Prescribing Information (FDA)


• Triazolam Monograph (AHFS DI)


• Triazolam Professional Patient Advice (Wolters Kluwer)


• Triazolam MedFacts Consumer Leaflet (Wolters Kluwer)


• Halcion Prescribing Information (FDA)

Compare triazolam with other medications

• Insomnia

Creomulsion

Generic Name: dextromethorphan (dex troe meth OR fan)

Brand Names: Babee Cof, Benylin DM Pediatric, Buckley's Mixture Cough Suppressant, Buckleys Mixture, Creo-Terpin, Creomulsion, Delsym, Delsym 12 Hour Cough Relief, Delsym 12 Hour Cough Relief for Children & Adults, DexAlone, Elixsure Cough, Hold DM, Pediacare, Robitussin CoughGels, Robitussin Honey Cough, Robitussin Maximum Strength, Robitussin Pediatric Cough Suppressant, Scot-Tussin Diabetic, Scot-Tussin DM Cough Chasers, Silphen DM, St. Joseph Cough Suppressant, Sucrets DM Cough, Theraflu Thin Strips Cough, Triaminic Long Acting Cough, Triaminic Softchew, Vicks 44 Cough Relief

What is Creomulsion (dextromethorphan)?

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Dextromethorphan is used to treat a cough.

Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.

Dextromethorphan may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Creomulsion (dextromethorphan)?

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not use dextromethorphan if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take dextromethorphan before the MAO inhibitor has cleared from your body. Do not use any other over-the-counter cough, cold, or allergy medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains dextromethorphan. Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.

What should I discuss with my healthcare provider before taking Creomulsion (dextromethorphan)?

Do not use dextromethorphan if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take dextromethorphan before the MAO inhibitor has cleared from your body.

Ask a doctor or pharmacist about using this medicine if you have emphysema or chronic bronchitis.

This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. This medication may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Artificially-sweetened liquid forms of cough medicine may contain phenylalanine. This would be important to know if you have phenylketonuria (PKU). Check the ingredients and warnings on the medication label if you are concerned about phenylalanine.

How should I take Creomulsion (dextromethorphan)?

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. Cough medicine is usually taken only for a short time until your symptoms clear up.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough or cold medicine in very young children.

Measure the liquid form of this medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Allow the dextromethorphan lozenge or disintegrating strip to dissolve in your mouth.

Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cough medicine within the past few days.

Store dextromethorphan at room temperature, away from heat, light, and moisture.

What happens if I miss a dose?

Since cough medicine is usually taken only as needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include feeling restless or nervous.

What should I avoid while taking Creomulsion (dextromethorphan)?

Avoid drinking alcohol. It can increase some of the side effects of dextromethorphan. This medication can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with cough medicine can increase your risk of unpleasant side effects.

Do not use any other over-the-counter cough, cold, or allergy medication without first asking your doctor or pharmacist. Dextromethorphan is contained in many combination medicines available over the counter. If you take certain products together you may accidentally take too much of this medicine. Read the label of any other medicine you are using to see if it contains dextromethorphan.

Creomulsion (dextromethorphan) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using dextromethorphan and call your doctor at once if you have any of these serious side effects:

• 
  

  severe dizziness, anxiety, restless feeling, or nervousness;

  
  


• 
  

  confusion, hallucinations; or

  
  


• 
  

  slow, shallow breathing.

  
  

Less serious side effects are more likely, such as stomach upset.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Creomulsion (dextromethorphan)?

Before taking dextromethorphan, tell your doctor if you are using any of the following drugs:

• 
  

  celecoxib (Celebrex);

  
  


• 
  

  cinacalcet (Sensipar);

  
  


• 
  

  darifenacin (Enablex);

  
  


• 
  

  imatinib (Gleevec);

  
  


• 
  

  quinidine (Quinaglute, Quinidex);

  
  


• 
  

  ranolazine (Ranexa)

  
  


• 
  

  ritonavir (Norvir);

  
  


• 
  

  sibutramine (Meridia);

  
  


• 
  

  terbinafine (Lamisil);

  
  


• 
  

  medicines to treat high blood pressure; or

  
  


• 
  

  antidepressant medications such as amitriptyline (Elavil, Etrafon), bupropion (Wellbutrin, Zyban), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Janimine, Tofranil), paroxetine (Paxil), sertraline (Zoloft), and others.

  
  

This list is not complete and there may be other drugs that can interact with dextromethorphan. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More Creomulsion resources

• Creomulsion Side Effects (in more detail)
• Creomulsion Use in Pregnancy & Breastfeeding
• Creomulsion Drug Interactions
• Creomulsion Support Group
• 0 Reviews for Creomulsion - Add your own review/rating

• Creomulsion Advanced Consumer (Micromedex) - Includes Dosage Information


• Delsym Extended-Release Liquid MedFacts Consumer Leaflet (Wolters Kluwer)


• DexAlone MedFacts Consumer Leaflet (Wolters Kluwer)


• Dextromethorphan Hydrobromide Monograph (AHFS DI)


• ElixSure Cough Gel Syrup MedFacts Consumer Leaflet (Wolters Kluwer)


• Robitussin Maximum Strength Liquid MedFacts Consumer Leaflet (Wolters Kluwer)


• Triaminic Long Acting Cough Orally Disintegrating Strips MedFacts Consumer Leaflet (Wolters Kluwer)


• Tussin Pediatric Elixir MedFacts Consumer Leaflet (Wolters Kluwer)

Compare Creomulsion with other medications

• Cough

Where can I get more information?

• Your pharmacist can provide more information about dextromethorphan.

See also: Creomulsion side effects (in more detail)

Capastat

Pronunciation: KAP-ree-oh-MYE-sin
Generic Name: Capreomycin
Brand Name: Capastat

Capastat should be used with extreme caution in patients with hearing or kidney problems, because it may increase hearing problems or kidney damage. Other injectable medicines used to treat tuberculosis (eg, streptomycin, viomycin) should not be used along with Capastat because the risk of hearing or kidney problems may be further increased. Other medicines that may cause hearing or kidney problems (eg, amikacin, colistin, gentamicin, kanamycin, neomycin, polymyxin A, tobramycin, vancomycin) should be used with extreme caution.

Safety and effectiveness of Capastat in pregnancy or in children have not been confirmed.

Capastat is used for:

Treating lung infections caused by certain strains of tuberculosis (TB). It is used with other medications, and it is only used in those patients who have not responded to or cannot use other specific medicines.

Capastat is a polypeptide antibiotic. It works by killing or stopping the growth of TB organisms.

Do NOT use Capastat if:

• you are allergic to any ingredient in Capastat


• you are taking other injectable medicines for TB (eg, streptomycin, viomycin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Capastat:

Some medical conditions may interact with Capastat. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have hearing problems, kidney problems, liver problems, blood electrolyte (eg, sodium, potassium) problems, Parkinson disease, nerve impairment, or myasthenia gravis

Some MEDICINES MAY INTERACT with Capastat. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Nondepolarizing muscle relaxants (eg, pancuronium) because their actions and the risk of their side effects may be increased by Capastat


• Amikacin, colistin, gentamicin, kanamycin, neomycin, polymyxin A, streptomycin, tobramycin, vancomycin, or viomycin because the risk of serious hearing or kidney side effects may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Capastat may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Capastat:

Use Capastat as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Capastat is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Capastat at home, a health care provider will teach you how to use it. Be sure you understand how to use Capastat. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.


• Do not use Capastat if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.


• Capastat may turn a pale straw color that might darken with time. This is normal.


• To clear up your infection completely, use Capastat for the full course of treatment. Keep using it even if you feel better in a few days.


• Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.


• If you miss a dose of Capastat, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Capastat.

Important safety information:

• Capastat only works against bacteria; it does not treat viral infections (eg, the common cold).


• Be sure to use Capastat for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.


• Long-term or repeated use of Capastat may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.


• Tell your doctor or dentist that you take Capastat before you receive any medical or dental care, emergency care, or surgery.


• Lab tests, including kidney function, liver function, blood calcium levels, blood potassium levels, blood magnesium levels, or hearing tests, may be performed while you use Capastat. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Capastat with caution in the ELDERLY; they may be more sensitive to its effects.


• Capastat is not recommended for use in CHILDREN; safety and effectiveness have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Capastat, contact your doctor. You will need to discuss the benefits and risks of using Capastat while you are pregnant. It is not know if Capastat is found in breast milk. If you are or will be breast feeding while you are using Capastat, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Capastat:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Pain, swelling, redness, or a hard lump at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); decreased hearing or hearing loss; decreased urination or other urination problems; fever, chills, or sore throat; hearing loss; ringing in the ears; sensation that the room is spinning; severe bleeding at the injection site; signs of electrolyte problems (eg, confusion; irregular heartbeat; mental or mood changes; muscle pain, weakness, or cramping).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Capastat side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dizziness; loss of ability to hear high tones; ringing in the ears; sensation that the room is spinning.

Proper storage of Capastat:

Capastat is usually handled and stored by a health care provider. If you are using Capastat at home, store Capastat as directed by your pharmacist or health care provider. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Capastat out of the reach of children and away from pets.

General information:

• If you have any questions about Capastat, please talk with your doctor, pharmacist, or other health care provider.


• Capastat is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Capastat. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Capastat resources

• Capastat Side Effects (in more detail)
• Capastat Use in Pregnancy & Breastfeeding
• Capastat Drug Interactions
• Capastat Support Group
• 0 Reviews for Capastat - Add your own review/rating

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Theophylline Sustained-Release Capsules

Pronunciation: thee-OF-i-lin
Generic Name: Theophylline
Brand Name: Theo 24

Theophylline Sustained-Release Capsules are used for:

Preventing and treating symptoms and blockage of airway due to asthma or other lung diseases (eg, emphysema, bronchitis). It may also be used for other conditions as determined by your doctor.

Theophylline Sustained-Release Capsules are a xanthine derivative. It works by relaxing the muscle around the airways in the lungs, which allows them to widen and makes breathing easier. It also improves contraction of the diaphragm (the major breathing muscle) and decreases the response of the airways to irritants.

Do NOT use Theophylline Sustained-Release Capsules if:

• you are allergic to any ingredient in Theophylline Sustained-Release Capsules, similar medicines (eg, aminophylline), or xanthines (eg, caffeine, chocolate)


• you are using large amounts of other products that contain xanthine (such as chocolate or caffeinated drinks)


• you are taking dipyridamole intravenously (IV), febuxostat, halothane, or St. John's wort

Contact your doctor or health care provider right away if any of these apply to you.

Before using Theophylline Sustained-Release Capsules:

Some medical conditions may interact with Theophylline Sustained-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a history of heart problems (eg, congestive heart failure, cor pulmonale), an irregular heartbeat, liver problems (eg, cirrhosis, hepatitis), viral infection, thyroid problems, increased acid levels in the body, brain or nerve problems, or seizures (eg, epilepsy)


• if you are in shock or have a fever, an ulcer, a severe infection, cystic fibrosis, or fluid in the lungs (pulmonary edema)


• if you smoke, are stopping or starting smoking, or are exposed to the smoke from cigarettes or marijuana


• if you are in the last 3 months of pregnancy

Some MEDICINES MAY INTERACT with Theophylline Sustained-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aminoglutethimide, barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), isoproterenol, moricizine, rifampin, St. John's wort, or sulfinpyrazone because they may decrease Theophylline Sustained-Release Capsules's effectiveness


• Allopurinol, beta-blockers (eg, propranolol), cimetidine, disulfiram, enoxacin, estrogen, febuxostat, fluvoxamine, interferon alpha, macrolide antibiotics (eg, clarithromycin, erythromycin), methotrexate, mexiletine, oral contraceptives (birth control pills), pentoxifylline, propafenone, quinolone antibiotics (eg, ciprofloxacin), tacrine, thiabendazole, ticlopidine, troleandomycin, verapamil, viloxazine, or zileuton because they may increase the risk of Theophylline Sustained-Release Capsules's side effects


• Ephedrine because the risk of side effects, such as nausea, nervousness, and trouble sleeping, may be increased


• Halothane because the risk of side effects such as irregular heartbeat may be increased


• Ketamine because the risk of seizures may be increased


• Adenosine, benzodiazepines (eg, diazepam, flurazepam, lorazepam, midazolam), dipyridamole IV, lithium, or nondepolarizing muscle relaxants (eg, pancuronium) because their effectiveness may be decreased by Theophylline Sustained-Release Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Theophylline Sustained-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Theophylline Sustained-Release Capsules:

Use Theophylline Sustained-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Some foods may change the effectiveness or increase the side effects of Theophylline Sustained-Release Capsules. Talk to your doctor about how you should take Theophylline Sustained-Release Capsules with regard to food. Do not suddenly change your diet or eating habits without first checking with your doctor.


• Swallow Theophylline Sustained-Release Capsules whole. Do not break, crush, or chew before swallowing.


• Take Theophylline Sustained-Release Capsules at about the same time(s) each day. If you are using more than 1 dose per day, try to take the second dose 10 to 12 hours after your first dose and before the evening meal. Check with your doctor or pharmacist if you have questions about how to take Theophylline Sustained-Release Capsules.


• If you are using 1 dose per day, take Theophylline Sustained-Release Capsules in the morning unless your doctor tells you otherwise.


• Continue to take Theophylline Sustained-Release Capsules even if you feel well. Do not miss any doses.


• If you miss a dose of Theophylline Sustained-Release Capsules, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Theophylline Sustained-Release Capsules.

Important safety information:

• Drinking alcohol may increase the risk of side effects of Theophylline Sustained-Release Capsules. Talk to your doctor before drinking alcohol while you are taking Theophylline Sustained-Release Capsules.


• Tell your doctor or dentist that you take Theophylline Sustained-Release Capsules before you receive any medical or dental care, emergency care, or surgery.


• Do not take more than the recommended dose or use more often than prescribed without checking with your doctor. If your symptoms become worse, contact your doctor.


• Carry an ID card at all times that says you take Theophylline Sustained-Release Capsules.


• Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate).


• Notify your doctor if you develop a new illness, especially if it is accompanied by fever; if a chronic illness becomes worse; or if you start or stop smoking cigarettes or marijuana.


• Tell your doctor if another doctor prescribes a new medicine or tells you to stop using a medicine that you have already been taking. Tell your doctor if you start or stop any medicine, either prescription or over the counter.


• Theophylline Sustained-Release Capsules will not stop an asthma attack once one has started. Be sure to always carry appropriate rescue medicine (eg, bronchodilator inhaler) with you in case of an asthma attack.


• If you have more than one doctor, be sure to tell each of your doctors that you are taking Theophylline Sustained-Release Capsules.


• Diabetes patients - Theophylline Sustained-Release Capsules may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.


• Theophylline Sustained-Release Capsules may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Theophylline Sustained-Release Capsules.


• Lab tests, including blood theophylline levels, may be performed while you use Theophylline Sustained-Release Capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.


• Use Theophylline Sustained-Release Capsules with caution in the ELDERLY; they may be more sensitive to its effects.


• Caution is advised when using Theophylline Sustained-Release Capsules in CHILDREN, especially children younger than 1 year old; they may be more sensitive to its effects. Children may be more likely to experience mild, temporary behavior changes.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Theophylline Sustained-Release Capsules while you are pregnant. Theophylline Sustained-Release Capsules are found in breast milk. If you are or will be breast-feeding while you use Theophylline Sustained-Release Capsules, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Theophylline Sustained-Release Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Irritability; mild, temporary caffeine-like effects (eg, headache, nausea, diarrhea, trouble sleeping); mild, temporary changes in behavior; restlessness; temporary increased urination.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; dizziness; fast breathing; fast or irregular heartbeat; heart rhythm problems; seizures; severe or persistent nausea, diarrhea, or headache; sleeplessness; tremors; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Theophylline side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include agitation; chest pain; confusion; decreased urination; fast or irregular heartbeat; headache; increased thirst; irritability; loss of appetite; muscle pain or tenderness; nausea; nervousness; persistent increased urination; restlessness; seizures; severe or persistent diarrhea; stomach pain; tremors or twitching; vomiting, especially of blood.

Proper storage of Theophylline Sustained-Release Capsules:

Store Theophylline Sustained-Release Capsules at room temperature below 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Theophylline Sustained-Release Capsules out of the reach of children and away from pets.

General information:

• If you have any questions about Theophylline Sustained-Release Capsules, please talk with your doctor, pharmacist, or other health care provider.


• Theophylline Sustained-Release Capsules are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Theophylline Sustained-Release Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Theophylline resources

• Theophylline Side Effects (in more detail)
• Theophylline Use in Pregnancy & Breastfeeding
• Drug Images
• Theophylline Drug Interactions
• Theophylline Support Group
• 5 Reviews for Theophylline - Add your own review/rating

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